EGFR S768_V769delinsIL(S768I&V769L)/BaF3
CBP73181
詢 價
留 言
產(chǎn)品描述
產(chǎn)品數(shù)據(jù)庫
| I. Introduction | |
| Cell Line Name： | EGFR S768_V769delinsIL(S768I&V769L)/BaF3 |
| Host Cell: | Ba/F3 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Application: | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
| Freeze Medium: | 90% FBS+10% DMSO |
| Complete Culture Medium: | RPMI-1640+10%FBS+2ug/ml puromycin |
| Mycoplasma Status: | Negative |
| II. Background | |
|
EGFR is the receptor for members of the EGF family and is a transmembrane glycoprotein that has tyrosine kinase activity. EGFR S768_V769delinsIL results in a deletion of two amino acids in the protein kinase domain of the Egfr protein from aa 768 to aa 769, combined with the insertion of an isoleucine (I) and a leucine (L) at the same site (UniProt.org). S768_V769delinsIL has been identified in the scientific literature (PMID: 17045698, PMID: 27304188), but has not been biochemically characterized and therefore, its effect on Egfr protein function is unknown (PubMed, Jul 2019). |
|
| III. Representative Data | |
|
1. WB of EGFR S768_V769delinsIL(S768I&V769L)/BaF3
|
|
|
2. Anti-proliferation assay |
